Kologrivova E N, Lepeshkova T S, Makoveeva S I
Vestn Otorinolaringol. 1996 Mar-Apr(2):29-31.
The study of mitogenic effect of autologous saliva in respect to peripheral blood lymphocytes of patients with different clinical forms of chronic tonsillitis (CT) discovered that saliva from all the examinees was highly active as regards blast-cell transformation. The intensity of lymphocyte blast-transformation in the presence of autologous saliva grows with CT transformation from compensated to decompensated form and insignificantly declines in clinical symptoms of autoimmune disease. The saliva mitogenic effect is probably stimulated by the whole complex of biologically active substances which by provoking hypertrophy of the lymphoid tissue contributes to autoimmunization of the body. It is proposed to use lymphocyte blast-transformation with autologous saliva for diagnosis of subclinical autoimmune diseases.
关于不同临床类型慢性扁桃体炎（CT）患者外周血淋巴细胞的自体唾液促有丝分裂作用的研究发现，所有受检者的唾液在胚细胞转化方面具有高度活性。在自体唾液存在的情况下，淋巴细胞胚细胞转化的强度随着CT从代偿型转变为失代偿型而增加，在自身免疫性疾病临床症状方面略有下降。唾液促有丝分裂作用可能受到生物活性物质整体复合物的刺激，这些物质通过刺激淋巴组织肥大促成机体自身免疫。建议使用自体唾液淋巴细胞胚细胞转化来诊断亚临床自身免疫性疾病。
