Mishra B, Mukherjee A, Girdhar A, Husain S, Malaviya G N, Girdhar B K
Central JALMA Institute for Leprosy Research (ICMR), Tajganj Agra, Inde.
Acta Leprol. 1995;9(4):187-94.
Sixteen neuritic cases have been seen developing cutaneous lesions. These cutaneous lesions by and large appear within 4 months after the diagnosis of neuritic leprosy. Leprosy pathology in cutaneous lesions has been found ranging between indeterminate and borderline lepromatous group. Development of cutaneous lesions does not seem to be influenced by age, sex or number of nerves or lepromin status. Neither lesions seem to appear in any particular part of the body. Therapy, duration and type i.e. monodrug or multidrug, also does not seem to influence the development of cutaneous lesions in either way. It appears that neuritic cases with either very early (indeterminate) or with advanced multibacillary neural pathology may develop skin lesions. Skin lesion possibly appear following reversal reaction in skin. Cases with newly developed skin lesions well respond to standard therapy. Development of cutaneous lesions by neuritic cases possibly indicates towards the natural history of the disease, conforming to the hypothesis that leprosy is basically neural in inception and that all other forms emerge from it.
已观察到16例神经炎型麻风患者出现皮肤损害。这些皮肤损害大体上在神经炎型麻风诊断后的4个月内出现。皮肤损害的麻风病理表现介于未定类和界线类偏瘤型之间。皮肤损害的发生似乎不受年龄、性别、神经数量或麻风菌素状态的影响。损害似乎也不出现在身体的任何特定部位。治疗方法、疗程及类型（即单药治疗或多药治疗）似乎也均不会以任何方式影响皮肤损害的发生。似乎极早期（未定类）或晚期多菌型神经病理改变的神经炎型麻风患者可能会出现皮肤损害。皮肤损害可能在皮肤发生逆转反应后出现。新出现皮肤损害的病例对标准治疗反应良好。神经炎型麻风患者出现皮肤损害可能表明了该病的自然病程，符合麻风病在发病初期基本是神经病变且所有其他类型均由此演变而来的假说。
