Parkash O, Kumar V, Mukherjee A, Sengupta U, Malaviya G N, Girdhar B K
Central JALMA Institute for Leprosy, Tajganj, Agra, India.
Acta Leprol. 1995;9(4):195-9.
Membrane attack complex (MAC) is a terminal end product produced as a result of complement activation. The deposition of MAC, in tissues, is known to have a local tissue damaging effect in several clinical conditions. Therefore, an attempt was made to demonstrate MAC in peripheral nerve biopsies, collected from leprosy patients. Interestingly, we could demonstrate deposition of MAC in involved cutaneous sensory nerves from most of the lepromatous leprosy patients. Contrary to this, majority of nerve biopsies from tuberculoid leprosy patients did not stain for MAC. Though MAC positive sections showed reactivity for S-protein, our observations support the possibility that MAC, either acting directly or indirectly, may be implicated in nerve damage, at least, in lepromatous leprosy patients.
膜攻击复合物（MAC）是补体激活产生的终末产物。已知在多种临床情况下，MAC在组织中的沉积具有局部组织损伤作用。因此，我们尝试在从麻风病患者采集的周围神经活检组织中检测MAC。有趣的是，我们能够在大多数瘤型麻风病患者受累的皮肤感觉神经中证实MAC的沉积。与此相反，结核样型麻风病患者的大多数神经活检组织MAC染色阴性。尽管MAC阳性切片对S蛋白有反应，但我们的观察结果支持这样一种可能性，即MAC至少在瘤型麻风病患者中，可能直接或间接参与了神经损伤。
