[采用HPLC柱切换技术研究米托蒽醌聚氰基丙烯酸酯纳米粒冻干注射剂的药代动力学]

[Study on pharmacokinetics of mitoxantrone polycyanoacrylate nanoparticles freeze-dried injection by HPLC column switching technique].

作者信息

Zhang Z R, Liao G T, Ye L M

机构信息

School of Pharmacy, West China University of Medical Sciences, Chengdu.

出版信息

Yao Xue Xue Bao. 1995 Nov;30(11):843-7.

PMID:8712010

Abstract

The drug concentration--time curves of mitoxantrone polycyanoacrylate nanoparticles freeze-dried injection (DHAQ-PBCA-NP-FDIn) and mitoxantrone solution injection (DHAQ-SIn) in rabbit blood were determined by HPLC column switching technique, and the difference between the DHAQ-PBCA-NP-FDIn and DHAQ-SIn in vivo was observed. The pharmacokinetic parameters of DHAQ-PBCA-NP-FDIn and DHAQ-SIn were presented by statistical moment. The results showed that the MRT and T1/2 of DHAQ-PBCA-NP-FDIn were 2.15 times longer than that of DHAQ-SIn, and the Vss was 4.81 times bigger than that of DHAQ-SIn. This indicates that DHAQ-PBCA-NP-FDIn has targeting and prolonging effect on the action in vivo.

摘要

采用HPLC柱切换技术测定了米托蒽醌聚氰基丙烯酸酯纳米粒冻干注射剂（DHAQ-PBCA-NP-FDIn）和米托蒽醌溶液注射剂（DHAQ-SIn）在兔血中的药物浓度-时间曲线，观察了DHAQ-PBCA-NP-FDIn与DHAQ-SIn在体内的差异。用统计矩法给出了DHAQ-PBCA-NP-FDIn和DHAQ-SIn的药代动力学参数。结果表明，DHAQ-PBCA-NP-FDIn的平均滞留时间（MRT）和半衰期（T1/2）分别是DHAQ-SIn的2.15倍，稳态分布容积（Vss）是DHAQ-SIn的4.81倍。这表明DHAQ-PBCA-NP-FDIn在体内具有靶向性和作用时间延长的效果。