Zhang Z R, Liao G T, Ye L M
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Yao Xue Xue Bao. 1995 Nov;30(11):843-7.
The drug concentration--time curves of mitoxantrone polycyanoacrylate nanoparticles freeze-dried injection (DHAQ-PBCA-NP-FDIn) and mitoxantrone solution injection (DHAQ-SIn) in rabbit blood were determined by HPLC column switching technique, and the difference between the DHAQ-PBCA-NP-FDIn and DHAQ-SIn in vivo was observed. The pharmacokinetic parameters of DHAQ-PBCA-NP-FDIn and DHAQ-SIn were presented by statistical moment. The results showed that the MRT and T1/2 of DHAQ-PBCA-NP-FDIn were 2.15 times longer than that of DHAQ-SIn, and the Vss was 4.81 times bigger than that of DHAQ-SIn. This indicates that DHAQ-PBCA-NP-FDIn has targeting and prolonging effect on the action in vivo.
采用HPLC柱切换技术测定了米托蒽醌聚氰基丙烯酸酯纳米粒冻干注射剂（DHAQ-PBCA-NP-FDIn）和米托蒽醌溶液注射剂（DHAQ-SIn）在兔血中的药物浓度-时间曲线，观察了DHAQ-PBCA-NP-FDIn与DHAQ-SIn在体内的差异。用统计矩法给出了DHAQ-PBCA-NP-FDIn和DHAQ-SIn的药代动力学参数。结果表明，DHAQ-PBCA-NP-FDIn的平均滞留时间（MRT）和半衰期（T1/2）分别是DHAQ-SIn的2.15倍，稳态分布容积（Vss）是DHAQ-SIn的4.81倍。这表明DHAQ-PBCA-NP-FDIn在体内具有靶向性和作用时间延长的效果。
