Zhou Jing, Jiang Xue-hua, He Lin, Li Chen-rui, Yang Jun-yi
Department of Clinical Pharmacy, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jan;37(1):145-7.
The pharmacokinetics of Cytarabine Polybutylcyanoacrylate Nanoparticles (Ara-C-PBCA-NP) lyophilization injection in rabbits was studied.
Ara-C water solution was taken as reference, the concentration of Ara-C was determined by HPLC, and the pharmacokinetic parameters were calculated.
Pharmacokinetic properties of Ara-C water solution and Ara-C-PBCA-NP lyophilization injection complied with two-department model. The parameters t1/2 beta and MRT of Ara-C-PBCA-NP lyophilization injection were prolonged, and CL was reduced dramatically (P < 0.05).
Ara-C-PBCA-NP lyophilization injection possesses prolonged retention time in vivo and significant sustained releasing character.
研究阿糖胞苷聚氰基丙烯酸丁酯纳米粒（Ara-C-PBCA-NP）冻干注射剂在兔体内的药代动力学。
以阿糖胞苷水溶液为对照，采用高效液相色谱法测定阿糖胞苷浓度，并计算药代动力学参数。
阿糖胞苷水溶液和阿糖胞苷-PBCA-NP冻干注射剂的药代动力学性质均符合二室模型。阿糖胞苷-PBCA-NP冻干注射剂的t1/2β和MRT参数延长，CL显著降低（P<0.05）。
阿糖胞苷-PBCA-NP冻干注射剂在体内具有较长的滞留时间和显著的缓释特性。
