Mao X M, Liang B W, Yao Y P, Fang S Z, Li Q
Chinese PLA No. 454 Hospital, Nanjing.
Yao Xue Xue Bao. 1995 Dec;30(12):881-5.
Iontophoresis of pulse current with various current intensity, frequency, on/off ratio and duration of treatment was used to facilitate the transdermal delivery of insulin in order to control blood glucose levels in diabetic rats. Male Sprague-Dawley rats were made diabetic by i.p. injection of streptozotocin (65 mg . kg-1 body weight). After two days, diabetic rats were anaesthetized with urethane (as 25% aqueous solution, 1.5 mg . g-1). Both the reservoir electrodes and the receptor electrodes were applied on the abdominal site of the diabetic rats. Iontophoresis was carried out using a prototype transdermal periodic iontophoretic system in order to provide the required direct current with desired pulse modes. The extent of reduction of blood glucose levels was found to be positively correlated with the current intensity, frequency and duration of treatment to some extent. But when the current intensity was over 0.8 mA/cm2 and the frequency was over 3000 Hz, the reduction of blood glucose levels did not continuously increase. Blood glucose levels were found to be better controlled when the on/off ratio of 1 : 1 was used.
采用不同电流强度、频率、通断比和治疗持续时间的脉冲电流离子电渗疗法，以促进胰岛素的经皮递送，从而控制糖尿病大鼠的血糖水平。通过腹腔注射链脲佐菌素（65mg·kg-1体重）使雄性Sprague-Dawley大鼠患糖尿病。两天后，用乌拉坦（作为25%的水溶液，1.5mg·g-1）麻醉糖尿病大鼠。将储存电极和接收电极都应用于糖尿病大鼠的腹部。使用原型经皮周期性离子电渗系统进行离子电渗疗法，以提供具有所需脉冲模式的所需直流电。发现血糖水平降低的程度在一定程度上与电流强度、频率和治疗持续时间呈正相关。但是当电流强度超过0.8mA/cm2且频率超过3000Hz时，血糖水平的降低并未持续增加。当使用1:1的通断比时，发现血糖水平得到更好的控制。
