Hourdry J, Gabrion J
Ann Endocrinol (Paris). 1977;38(1):27-39.
The stable, bound iodine in the thyroid colloid of Triturus helveticus has been studied with the electron microprobe. Some animals show a normal development. Others are accidentally neotenic due to certain ecological conditions. The values of punctate iodine concentrations (CPI) have been computed and expressed in relative units (counts/s). The mean CPI per lumen is very variable from one follicle to another in the same thyroid section. During normal development, the mean CPI per animal is generally higher in metamorphosing individuals than in larvae. During development with neoteny, the mean CPI per animal attains high values if the larval state is maintained in its totality; the CPI decreases in partially metamorphosed animals, but increases again after metamorphosis. The amount of halogen contained in the thyroid colloid has been computed in relative units (colloid iodine pool). Throughout normal development, the pool remains small if the animals have not attained the adult state. In increases considerably in entirely larval neotenic newts, decreases during metamorphosis but increases afterwards. In totally neotenic newts, the thyroid gland receives only a low hypophyseal stimulation and reacts as the thyroid gland of various hypophysectomized Urodeles. Our results pose the problem as to whether TSH regulates the transepithelial iodine flows, which permit the expansion of the colloid iodine pool, when this hormone is secreted at a very low levels.
已使用电子微探针研究了瑞士产蝾螈甲状腺胶体中稳定的结合碘。一些动物发育正常。其他动物由于某些生态条件而意外出现幼态持续。已计算出点状碘浓度（CPI）的值，并以相对单位（计数/秒）表示。在同一甲状腺切片中，每个腺泡腔的平均CPI值在不同腺泡之间差异很大。在正常发育过程中，正在变态的个体中每只动物的平均CPI通常高于幼虫。在幼态持续发育过程中，如果幼虫状态完全维持，每只动物的平均CPI会达到很高的值；在部分变态的动物中，CPI会降低，但在变态后又会增加。已以相对单位（胶体碘池）计算了甲状腺胶体中所含卤素的量。在整个正常发育过程中，如果动物尚未达到成年状态，胶体碘池仍然很小。在完全幼态持续的幼体蝾螈中，胶体碘池会大幅增加，在变态过程中减少，但之后又会增加。在完全幼态持续的蝾螈中，甲状腺仅受到低水平的垂体刺激，其反应类似于各种垂体切除的有尾目动物的甲状腺。我们的结果提出了一个问题，即当促甲状腺激素（TSH）以非常低的水平分泌时，它是否调节允许胶体碘池扩大的跨上皮碘流。
