双相情感障碍患者一级亲属中MAO活性降低。初步报告。

Reduced MAO activity in first-degree relatives of individuals with bipolar affective disorders. A preliminary report.

作者信息

Leckman J F, Gershon E S, Nichols A S, Murphy D L

出版信息

Arch Gen Psychiatry. 1977 May;34(5):601-6. doi: 10.1001/archpsyc.1977.01770170111011.

DOI:10.1001/archpsyc.1977.01770170111011

Abstract

Previous reports have indicated that platelet monoamine oxidase (MAO) activity is reduced in patients with the bipolar form of major affective illness. We present evidence that platelet MAO activity is also significantly reduced in the first-degree relatives of bipolar patients. However, platelet MAO activity did not distinguish ill from well family members. It is possible that reduced platelet MAO may be an indicator of increased familial vulnerability to affective disorders.

摘要

先前的报告表明，在双相型重度情感障碍患者中，血小板单胺氧化酶（MAO）活性降低。我们提供的证据表明，双相情感障碍患者的一级亲属中血小板MAO活性也显著降低。然而，血小板MAO活性无法区分患病和健康的家庭成员。血小板MAO降低可能是家族性情感障碍易感性增加的一个指标。