甲状旁腺激素相关蛋白、骨转移和恶性肿瘤高钙血症
Parathyroid hormone-related protein, bone metastases and hypercalcaemia of malignancy.
作者信息
Bundred N J, Walls J, Ratcliffe W A
机构信息
University Hospital of South Manchester, West Didsbury.
出版信息
Ann R Coll Surg Engl. 1996 Jul;78(4):354-8.
Breast cancer patients frequently develop bone metastases. A newly discovered peptide, Parathyroid Hormone Related Protein (PTHrP), causes humoral hypercalcaemia of malignancy. We have studied whether production of this protein by breast cancers leads to the development of bone metastases or hypercalcaemia. PTHrP was produced by nearly 60% of early breast cancers and its production by the tumours was associated with malignant mammographic microcalcification, and the development of both bone metastases and hypercalcaemia. The hypercalcaemia associated with bone metastases has been shown to have a significant humoral component and measurement of plasma PTHrP in patients with hypercalcaemia is diagnostically useful. Potential mechanisms of preventing bone metastasis are discussed.
乳腺癌患者经常会发生骨转移。一种新发现的肽，甲状旁腺激素相关蛋白（PTHrP），会导致恶性肿瘤的体液性高钙血症。我们研究了乳腺癌产生这种蛋白质是否会导致骨转移或高钙血症的发生。近60%的早期乳腺癌会产生PTHrP，肿瘤产生PTHrP与恶性乳腺钼靶微钙化、骨转移和高钙血症的发生有关。与骨转移相关的高钙血症已被证明具有显著的体液成分，对高钙血症患者测量血浆PTHrP具有诊断价值。文中还讨论了预防骨转移的潜在机制。
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