Niles J L
Department of Medicine, Massachusetts General Hospital, Boston 02114, USA.
Annu Rev Med. 1996;47:303-13. doi: 10.1146/annurev.med.47.1.303.
Two important types of antineutrophil cytoplasmic antibodies (ANCA) have been identified: anti-proteinase 3 and anti-myeloperoxidase antibodies. In the appropriate clinical setting, the presence of either is virtually diagnostic of the subset of vasculitis that includes Wegener's granulomatosis, microscopic polyangiitis (microscopic polyarteritis), the Churg-Strauss syndrome, idiopathic pauci-immune necrotizing and crescentic glomerulonephritis, and related and overlapping forms of these vasculitidies. The finding of ANCA throughout this group identifies these syndromes as belonging to a single category or spectrum of disease.
已鉴定出两种重要的抗中性粒细胞胞浆抗体（ANCA）：抗蛋白酶3抗体和抗髓过氧化物酶抗体。在适当的临床背景下，这两种抗体中的任何一种的存在实际上都可诊断出血管炎的一个亚组，该亚组包括韦格纳肉芽肿、显微镜下多血管炎（显微镜下多动脉炎）、变应性肉芽肿性血管炎、特发性寡免疫坏死性和新月形肾小球肾炎，以及这些血管炎的相关和重叠形式。在整个这组疾病中发现ANCA表明这些综合征属于单一类别或疾病谱。
