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老年患者胆源性胰腺炎的安全腹腔镜内镜联合治疗方法。

Safe laparoendoscopic approach to biliary pancreatitis in older patients.

作者信息

McGrath M F, McGrath J C, Gabbay J, Phillips E H, Hiatt J R

机构信息

Department of Surgery, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, USA.

出版信息

Arch Surg. 1996 Aug;131(8):826-31; discussion 831-3. doi: 10.1001/archsurg.1996.01430200036006.

Abstract

OBJECTIVE

To evaluate management strategies for biliary pancreatitis in different age groups.

DESIGN

Retrospective review.

SETTING

Large private metropolitan teaching hospital.

PATIENTS

Patients seen between January 1991 and December 1994 with a diagnosis of biliary pancreatitis (N = 136) divided into 2 groups (group 1, aged < 65 years; group 2, aged > or = 65 years).

INTERVENTIONS

Primary treatments included endoscopic retrograde cholangiography (n = 36) alone or with endoscopic sphincterotomy (n = 27); operative procedures, including cholecystectomy by laparoscopic (n = 54) or open (n = 16) approaches; or no definitive therapy (n = 22). Secondary treatments of common bile duct stones included laparoscopic transcystic bile duct exploration (n = 5), open common bile duct exploration (n = 4), or postoperative endoscopic retrograde cholangiography (n = 10).

MAIN OUTCOME MEASURES

Success of interventions, incidence and treatment of common bile duct stones, morbidity and mortality rates, frequency of retained stones, and length of hospitalization.

RESULTS

Numbers of Ranson criteria were higher for older patients (group 1, 0.83 +/- 0.12 vs group 2, 1.57 +/- 0.11 [mean +/- SEM]; P < .001). Primary endoscopic retrograde cholangiography with or without endoscopic sphincterotomy was performed earlier than operative procedures, with a significantly higher incidence of common bile duct stones (72% vs 19%; P < .001). Number of primary procedures and complication and mortality rates for endoscopic retrograde cholangiography with or without endoscopic sphincterotomy were 36, 8%, and 3%, respectively; for laparoscopic cholecystectomy, 54, 9%, and 2%, respectively; and for open cholecystectomy, 16, 6%, and 19%, respectively. For complication and mortality rates, there were no statistical differences between groups or among treatments. Deferred therapy was used in 30 patients, with 20% readmitted for recurrence of biliary pancreatitis. Length of intensive care unit and total hospital stay were similar for all groups and treatments.

CONCLUSIONS

Older patients with biliary pancreatitis may be safely treated with a combined laparoendoscopic approach. Management of common bile duct stones depends on age, with laparoscopic transcystic duct exploration or open common bile duct exploration preferred for younger patients and laparoscopic transcystic duct exploration or postoperative endoscopic sphincterotomy for older ones. Deferred therapy has a substantial relapse rate.

摘要

目的

评估不同年龄组胆源性胰腺炎的治疗策略。

设计

回顾性研究。

地点

大型私立都市教学医院。

患者

1991年1月至1994年12月期间诊断为胆源性胰腺炎的患者(N = 136),分为两组(第1组,年龄<65岁;第2组,年龄≥65岁)。

干预措施

主要治疗方法包括单独内镜逆行胰胆管造影(n = 36)或联合内镜括约肌切开术(n = 27);手术操作,包括腹腔镜胆囊切除术(n = 54)或开腹胆囊切除术(n = 16);或不进行确定性治疗(n = 22)。胆总管结石的二级治疗包括腹腔镜经胆囊管胆管探查术(n = 5)、开腹胆总管探查术(n = 4)或术后内镜逆行胰胆管造影(n = 10)。

主要观察指标

干预措施的成功率、胆总管结石的发生率及治疗情况、发病率和死亡率、残留结石的发生率以及住院时间。

结果

老年患者的兰森标准数量更高(第1组,0.83±0.12 vs第2组,1.57±0.11[平均值±标准误];P <.001)。单独或联合内镜括约肌切开术的内镜逆行胰胆管造影术比手术操作更早进行,胆总管结石的发生率显著更高(72%对19%;P <.001)。单独或联合内镜括约肌切开术的内镜逆行胰胆管造影术的主要手术数量、并发症发生率和死亡率分别为36、8%和3%;腹腔镜胆囊切除术分别为54、9%和2%;开腹胆囊切除术分别为16、6%和19%。对于并发症发生率和死亡率,各组之间或各治疗方法之间无统计学差异。30例患者采用延迟治疗,其中20%因胆源性胰腺炎复发再次入院。所有组和治疗方法的重症监护病房住院时间和总住院时间相似。

结论

老年胆源性胰腺炎患者可安全地采用腹腔镜联合内镜的方法进行治疗。胆总管结石的治疗取决于年龄,年轻患者首选腹腔镜经胆囊管探查术或开腹胆总管探查术,老年患者首选腹腔镜经胆囊管探查术或术后内镜括约肌切开术。延迟治疗有较高的复发率。

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