Raĭkhlin N T, Smirnov E A, Perevoshchikov A G
Arkh Patol. 1996 Mar-Apr;58(2):3-8.
Development of apoptosis was followed up in the cell line LIM-1863 of human colon carcinoma and in the same cell line with multiple drug resistance (MDR) related to the expression of gene mdr I and hyperproduction of protein P-glycoprotein 170 encoded by this gene. The number of cells with histological and ultrastructural features of apoptosis increased with acquirement by tumor cells of typical MDR. The enhancement of apoptosis in tumor cells with MDR results probably from the increase of cells with signs of terminal differentiation which is one of apoptosis inducers. Mitotic activity in both lines did not change essentially, but the original line had a more rapid growth than its analogue with MDR. Elimination of cells through apoptosis may be the cause of slower growth of the cell line with apoptosis. The rate of tumor growth depends on the balance between proliferative activity and apoptosis.
对人结肠癌LIM - 1863细胞系以及与mdr I基因表达和该基因编码的P - 糖蛋白170过度产生相关的多重耐药（MDR）的同一细胞系中的细胞凋亡发展情况进行了跟踪研究。具有凋亡组织学和超微结构特征的细胞数量随着肿瘤细胞获得典型的MDR而增加。MDR肿瘤细胞中凋亡的增强可能是由于具有终末分化迹象的细胞增加所致，而终末分化是凋亡诱导因素之一。两个细胞系中的有丝分裂活性基本没有变化，但原始细胞系比其具有MDR的类似细胞系生长更快。通过凋亡消除细胞可能是具有MDR的细胞系生长较慢的原因。肿瘤生长速率取决于增殖活性和凋亡之间的平衡。
