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Involvement of the N-terminal part of cyclophilin B in the interaction with specific Jurkat T-cell binding sites.亲环蛋白B的N端部分参与与特定的Jurkat T细胞结合位点的相互作用。
Biochem J. 1996 Jul 15;317 ( Pt 2)(Pt 2):571-6. doi: 10.1042/bj3170571.
2
Evidence that human milk isolated cyclophilin B corresponds to a truncated form.人乳中分离出的亲环蛋白B为截短形式的证据。
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Distribution of cyclophilin B-binding sites in the subsets of human peripheral blood lymphocytes.亲环蛋白B结合位点在人外周血淋巴细胞亚群中的分布。
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Receptor type I and type II binding regions and the peptidyl-prolyl isomerase site of cyclophilin B are required for enhancement of T-lymphocyte adhesion to fibronectin.亲环素B的I型和II型受体结合区域以及肽基脯氨酰异构酶位点是增强T淋巴细胞与纤连蛋白黏附所必需的。
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Cyclophilin B mediates cyclosporin A incorporation in human blood T-lymphocytes through the specific binding of complexed drug to the cell surface.亲环蛋白B通过复合药物与细胞表面的特异性结合介导环孢素A进入人血T淋巴细胞。
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Involvement of two classes of binding sites in the interactions of cyclophilin B with peripheral blood T-lymphocytes.亲环蛋白B与外周血T淋巴细胞相互作用中两类结合位点的参与情况。
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Hsp47 and cyclophilin B traverse the endoplasmic reticulum with procollagen into pre-Golgi intermediate vesicles. A role for Hsp47 and cyclophilin B in the export of procollagen from the endoplasmic reticulum.热休克蛋白47（Hsp47）和亲环素B与前胶原一起穿过内质网进入高尔基前中间囊泡。Hsp47和亲环素B在内质网中前胶原输出过程中的作用。
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Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.人亲环蛋白B：第二个亲环蛋白基因编码一种带有信号序列的肽基脯氨酰异构酶。
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X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.亲环蛋白B/环孢素复合物的X射线结构：与亲环蛋白A的比较及其钙调神经磷酸酶结合域的描绘
Proc Natl Acad Sci U S A. 1994 May 24;91(11):5183-6. doi: 10.1073/pnas.91.11.5183.

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Proc Natl Acad Sci U S A. 2002 May 14;99(10):6790-5. doi: 10.1073/pnas.092160699. Epub 2002 May 7.
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Delineation of the calcineurin-interacting region of cyclophilin B.亲环蛋白B与钙调神经磷酸酶相互作用区域的描绘。
Protein Sci. 2000 Dec;9(12):2386-93. doi: 10.1110/ps.9.12.2386.
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Involvement of two classes of binding sites in the interactions of cyclophilin B with peripheral blood T-lymphocytes.亲环蛋白B与外周血T淋巴细胞相互作用中两类结合位点的参与情况。
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4
Distribution of cyclophilin B-binding sites in the subsets of human peripheral blood lymphocytes.亲环蛋白B结合位点在人外周血淋巴细胞亚群中的分布。
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5
Presence of cyclophilin A in synovial fluids of patients with rheumatoid arthritis.类风湿关节炎患者滑液中环孢素A的存在。
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本文引用的文献

1
Cyclophilin B mediates cyclosporin A incorporation in human blood T-lymphocytes through the specific binding of complexed drug to the cell surface.亲环蛋白B通过复合药物与细胞表面的特异性结合介导环孢素A进入人血T淋巴细胞。
Biochem J. 1996 Jul 15;317 ( Pt 2)(Pt 2):565-70. doi: 10.1042/bj3170565.
2
Cloning and characterization of cyclophilin C-associated protein: a candidate natural cellular ligand for cyclophilin C.亲环蛋白C相关蛋白的克隆与特性分析：亲环蛋白C的一种潜在天然细胞配体
Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6815-9. doi: 10.1073/pnas.90.14.6815.
3
Interleukin-8 is a cyclosporin A binding protein.
Experientia. 1993 Jul 5;49(6-7):533-8. doi: 10.1007/BF01955157.
4
Characterization of surface binding sites for cyclophilin B on a human tumor T-cell line.
J Biol Chem. 1994 Jun 17;269(24):16537-40.
5
X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.亲环蛋白B/环孢素复合物的X射线结构：与亲环蛋白A的比较及其钙调神经磷酸酶结合域的描绘
Proc Natl Acad Sci U S A. 1994 May 24;91(11):5183-6. doi: 10.1073/pnas.91.11.5183.
6
A novel peptidyl-prolyl cis/trans isomerase from Escherichia coli.一种来自大肠杆菌的新型肽基脯氨酰顺/反异构酶。
FEBS Lett. 1994 Apr 18;343(1):65-9. doi: 10.1016/0014-5793(94)80608-x.
7
Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.亲环素B通过分泌途径的运输因环孢素A的结合而改变。
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3931-5. doi: 10.1073/pnas.91.9.3931.
8
Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies.
J Immunol Methods. 1995 Jan 13;178(1):113-20. doi: 10.1016/0022-1759(94)00249-v.
9
The role of Tyr13 and Lys15 of interleukin-8 in the high affinity interaction with the interleukin-8 receptor type A.白细胞介素-8的酪氨酸13和赖氨酸15在与A型白细胞介素-8受体的高亲和力相互作用中的作用。
J Biol Chem. 1995 May 5;270(18):10428-31. doi: 10.1074/jbc.270.18.10428.
10
Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.鉴定能够介导环孢菌素A和FK506对信号转导抑制作用的亲免素：钙调神经磷酸酶结合及细胞定位的作用
Mol Cell Biol. 1993 Aug;13(8):4760-9. doi: 10.1128/mcb.13.8.4760-4769.1993.

亲环蛋白B的N端部分参与与特定的Jurkat T细胞结合位点的相互作用。

Involvement of the N-terminal part of cyclophilin B in the interaction with specific Jurkat T-cell binding sites.

作者信息

Mariller C, Haendler B, Allain F, Denys A, Spik G

机构信息

Laboratoire de Chimie Biologique, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.

出版信息

Biochem J. 1996 Jul 15;317 ( Pt 2)(Pt 2):571-6. doi: 10.1042/bj3170571.

DOI:10.1042/bj3170571
PMID:8713087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1217524/
Abstract

Cyclophilin B (CyPB) is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes. This study was intended to specify the areas of CyPB that are involved in the interaction with the receptor. A synthetic peptide corresponding to the first 24 N-terminal amino acid residues of CyPB was shown to specifically recognize the receptor. Moreover, modification of Arg18 of CyPB by p-hydroxyphenlglyoxal led to a dramatic loss of affinity for the receptor. However, when this residue was replaced by an alanine residue using site-directed mutagenesis, no modification of the binding properties was found, suggesting that Arg18 is not directly involved but is sufficiently close to the interaction site to interfere with the binding when modified. Competitive binding experiments using a chimaeric protein made up of the 24 N-terminal amino acid residues of CyPB fused to the cyclophilin A core sequence confirmed the involvement of this region of CyPB in receptor binding.

摘要

亲环蛋白B（CyPB）分泌于血液或乳汁等生物体液中，并与人类淋巴细胞系Jurkat及人外周血淋巴细胞上存在的特定受体结合。本研究旨在明确CyPB中参与与该受体相互作用的区域。一段与CyPB前24个N端氨基酸残基对应的合成肽被证明能特异性识别该受体。此外，对苯乙二醛对CyPB的精氨酸18进行修饰导致其对受体的亲和力急剧丧失。然而，当使用定点诱变将该残基替换为丙氨酸残基时，未发现结合特性有改变，这表明精氨酸18并非直接参与其中，但它与相互作用位点足够接近，以至于修饰时会干扰结合。使用由与亲环蛋白A核心序列融合的CyPB的24个N端氨基酸残基组成的嵌合蛋白进行的竞争性结合实验证实了CyPB的这一区域参与受体结合。