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[使用动脉同种异体移植物治疗假体 - 消化系统疾病]

[Treatment of prostheto-digestive using arterial allograft].

作者信息

Bahnini A, Plissonnier D, Koskas F, Kieffer E

机构信息

Service de Chirurgie Vasculaire, G. H. Pitié-Salpétrière, Paris.

出版信息

J Mal Vasc. 1996;21 Suppl A:167-70.

PMID:8713388
Abstract

From October 1988 to March 1995, we operated 22 patients for fistulization between the prosthesis and the digestive tract to remove the in situ allograft. The delay between the initial operation and treatment for fistulization was 7.3 +/- 4 years. In these patients who had undergone multiple operations (2.5 +/- 1.9 operations per patient), the infected prosthesis was made of Dacron in 21 cases and polytetrafluoroethylene in one. The procedure was planned beforehand in 21 cases who benefited from a complete preoperative work-up and was required in an emergency situation in 6 for digestive bleeding (5 cases) or an abscess of the Scarpa (1 case). Among the patients with an emergency operation, three of the procedures were conducted within a single operative time and three with two separate procedures. The allografts were aorto-aortic tubes (n = 3), aortobifemoral bypasses (n = 14), aorto-iliac bypasses (n = 4) and one aorto-femoral-iliac bypass. Organ revascularization was associated in 8 patients. Seven patients (32%) died post-operatively. Five of them had undergone an emergency procedure. An amputation was required in 2 patients, one at the time the allograft was implanted and the second due to ischaemia despite a permeable allograft. None of the patients had to be amputated due to failure of the allograft. Mean follow-up was 36.6 +/- 20 months. There were 4 deaths post-operatively due to digestive bleeding in 2. The aortic allograft was dilated in 4 patients without re-operation. Thrombosis of the allograft branch occurred in 4 patients, including 3 who had been re-operated successfully. Despite these still perfectable results, treatment of secondary digestive-prosthesis fistulae with an in situ allograft constitutes a real progress in terms of patient survival and preservation of the limb in high-risk patients.

摘要

1988年10月至1995年3月,我们对22例患者进行了假体与消化道之间的瘘管手术,以取出原位同种异体移植物。初次手术与瘘管治疗之间的间隔时间为7.3±4年。这些患者均接受过多次手术(每位患者平均2.5±1.9次手术),其中21例患者的感染假体由涤纶制成,1例由聚四氟乙烯制成。21例患者术前进行了全面检查并预先制定了手术方案,6例因消化道出血(5例)或斯卡帕脓肿(1例)在紧急情况下进行了手术。在急诊手术的患者中,3例手术在一次手术时间内完成,3例分两次手术进行。同种异体移植物包括主动脉-主动脉管(n = 3)、主动脉-双股动脉旁路移植术(n = 14)、主动脉-髂动脉旁路移植术(n = 4)和1例主动脉-股动脉-髂动脉旁路移植术。8例患者同时进行了器官血运重建。7例患者(32%)术后死亡。其中5例接受了急诊手术。2例患者需要截肢,1例在植入同种异体移植物时截肢,另1例尽管同种异体移植物通畅但因缺血而截肢。没有患者因同种异体移植物失败而截肢。平均随访时间为36.6±20个月。术后有4例患者因消化道出血死亡,其中2例。4例患者的主动脉同种异体移植物扩张但未再次手术。4例患者发生同种异体移植物分支血栓形成,其中3例成功进行了再次手术。尽管这些结果仍有改进空间,但对于高危患者,原位同种异体移植物治疗继发性消化道-假体瘘在患者生存和肢体保留方面确实取得了进展。

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