Lall R, Dhanda V
Vector Control Research Centre, Indira Nagar, Pondicherry, India.
Natl Med J India. 1996 Jan-Feb;9(1):20-3.
The clinical spectrum of dengue fever ranges from asymptomatic infection through severe haemorrhage and sudden fatal shock. Increased capillary permeability is the diagnostic feature of dengue haemorrhagic fever (DHF). The pathophysiology of DHF/dengue shock syndrome (DSS) is related to sequential infection with different serotypes of the virus, variations in virus virulence, interaction of the virus with environmental or host factors and a combination of various risk factors. Infection due to low virulence strains is assumed to be the reason for the infrequent incidence of serious dengue disease in India. Since all four serotypes of the dengue virus have been implicated in various outbreaks in this country and several outbreaks of DHF/DSS have been recorded since the first report in 1963, further epidemics of the disease are likely. The situation is aggravated by the recent emergence of DHF/DSS in Sri Lanka. In view of the potential of this disease to spread, effective preventive and control measures should be a priority.
登革热的临床谱范围从无症状感染到严重出血和突然致命性休克。毛细血管通透性增加是登革出血热（DHF）的诊断特征。DHF/登革休克综合征（DSS）的病理生理学与病毒不同血清型的连续感染、病毒毒力的变化、病毒与环境或宿主因素的相互作用以及各种危险因素的组合有关。低毒力毒株感染被认为是印度严重登革热疾病发病率低的原因。由于登革病毒的所有四种血清型都与该国的各种疫情有关，并且自1963年首次报告以来已记录了几起DHF/DSS疫情，因此该疾病可能会进一步流行。斯里兰卡最近出现DHF/DSS使情况更加恶化。鉴于这种疾病的传播潜力，有效的预防和控制措施应成为优先事项。
