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[载脂蛋白B-100蛋白拟低密度脂蛋白结合域编码区域的APOV基因不存在DNA多态性]

[Absence of DNA polymorphisms on the region of the APOV gene coding the proposed low density lipoprotein-binding domain of the ApoB-100 protein].

作者信息

Shevtsov S P

出版信息

Genetika. 1996 Feb;32(2):295-7.

PMID:8713626
Abstract

To reveal the molecular basis of hereditary diathesis to hypercholesterolemia, single-strand conformation polymorphism (SSCP) analysis and subsequent sequencing were used to study structural organization of the APOB gene for apolipoprotein B-100 (ApoB-100). The gene region encoding a putative low density lipoprotein (LDL) receptor binding domain was analyzed in patients with myocardial infarction (MI). Differences in structure of the gene between patients with MI and healthy people were not detected.

摘要

为揭示高胆固醇血症遗传素质的分子基础，采用单链构象多态性（SSCP）分析及后续测序研究载脂蛋白B-100（ApoB-100）的APOB基因结构组织。对心肌梗死（MI）患者分析了编码假定低密度脂蛋白（LDL）受体结合域的基因区域。未检测到MI患者与健康人之间的基因结构差异。

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ApoB-100 R3500Q mutation in the Lebanese population: prevalence and historical review of the literature.黎巴嫩人群中载脂蛋白B-100的R3500Q突变：文献综述及患病率
Mol Biol Rep. 2007 Dec;34(4):267-70. doi: 10.1007/s11033-006-9041-7. Epub 2006 Dec 8.
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Familial hypercholesterolemia in St-Petersburg: the known and novel mutations found in the low density lipoprotein receptor gene in Russia.圣彼得堡的家族性高胆固醇血症：俄罗斯在低密度脂蛋白受体基因中发现的已知和新突变
BMC Med Genet. 2005 Feb 8;6:6. doi: 10.1186/1471-2350-6-6.