[Absence of DNA polymorphisms on the region of the APOV gene coding the proposed low density lipoprotein-binding domain of the ApoB-100 protein].

To reveal the molecular basis of hereditary diathesis to hypercholesterolemia, single-strand conformation polymorphism (SSCP) analysis and subsequent sequencing were used to study structural organization of the APOB gene for apolipoprotein B-100 (ApoB-100). The gene region encoding a putative low density lipoprotein (LDL) receptor binding domain was analyzed in patients with myocardial infarction (MI). Differences in structure of the gene between patients with MI and healthy people were not detected.