Varvarigou A, Vagenakis A G, Makri M, Frimas C, Beratis N G
Department of Paediatrics, University of Patras Medical School, General University Hospital, Greece.
Biol Neonate. 1996;69(2):76-83. doi: 10.1159/000244281.
To assess the pituitary response to perinatal asphyxia, the prolactin (PRL) and growth hormone (hGH) serum concentrations were measured in 55 asphyctic (15 preterm and 40 full-term) and 35 control (15 preterm and 20 full-term) newborns at 2-4, 24, 48 and 98 h of life. At 2-4 h the median PRL in the preterm asphyctic neonates was 5.2 U/l, whereas in the preterm control newborns it was 3.2. In the full-term newborns with and without hypoxic-ischaemic encephalopathy (HIE) it was 5.8 and 3.4, respectively. In the full-term neonates with HIE the PRL remained significantly higher than in the controls up to the fourth day. At 2-4 h the median hGH in the preterm asphyctic and control newborns was 106.2 and 54.8 mU/l, respectively. In full-term newborns it was 85.0 and 40.8, respectively. The lowest hGH concentrations were found in the severe HIE. The increased PRL and hGH in asphyxia may result from a stress-related hormone release, whereas the very low hGH concentrations in severe HIE may result from a damage at the hypothalamic-hypophyseal axis.
为评估围产期窒息时垂体的反应，我们测定了55例窒息新生儿（15例早产儿和40例足月儿）和35例对照新生儿（15例早产儿和20例足月儿）出生后2 - 4小时、24小时、48小时和98小时的血清催乳素（PRL）和生长激素（hGH）浓度。在2 - 4小时时，早产窒息新生儿的PRL中位数为5.2 U/l，而早产对照新生儿为3.2 U/l。在有和无缺氧缺血性脑病（HIE）的足月儿中，PRL分别为5.8和3.4 U/l。在有HIE的足月儿中，直到第四天PRL仍显著高于对照组。在2 - 4小时时，早产窒息新生儿和对照新生儿的hGH中位数分别为106.2和54.8 mU/l。在足月儿中分别为85.0和40.8 mU/l。严重HIE患儿的hGH浓度最低。窒息时PRL和hGH升高可能是应激相关激素释放所致，而严重HIE时hGH浓度极低可能是下丘脑 - 垂体轴受损所致。
