Mayer A P, Greenberg M L
Department of Tissue Pathology, Westmead Hospital, NSW.
Pathology. 1996 Jan;28(1):90-5. doi: 10.1080/00313029600169623.
A 48 yr old HIV seropositive female presented with a right breast mass and bilateral axillary lymphadenopathy. Fine needle biopsy (FNB) revealed an adenocarcinoma with abundant mucin production and features suggestive of a cribriform and micropapillary ductal carcinoma in situ (DCIS). Histopathological examination of the tumor confirmed an invasive mixed colloid carcinoma with extensive DCIS. There have been 4 previous reports in the literature of breast carcinoma associated with HIV seropositivity. This case initially diagnosed by FNB is the first case reported in Australia. In spite of the somewhat more favourable histological type of breast carcinoma, this tumor shows numerous unfavourable prognostic factors and has had an aggressive clinical course with relapse of disease in the contralateral breast and distant metastases within 4 wks of surgery, probably related to the patient's immunodeficiency.
一名48岁的HIV血清阳性女性出现右乳肿块及双侧腋窝淋巴结肿大。细针穿刺活检（FNB）显示为腺癌，有大量黏液产生，具有筛状和微乳头状导管原位癌（DCIS）的特征。肿瘤的组织病理学检查证实为伴有广泛DCIS的浸润性混合性胶样癌。文献中此前有4例与HIV血清阳性相关的乳腺癌报道。该病例最初通过FNB诊断，是澳大利亚报道的首例。尽管该乳腺癌的组织学类型在一定程度上较为有利，但此肿瘤显示出众多不良预后因素，且临床过程具有侵袭性，术后4周内对侧乳房出现疾病复发及远处转移，这可能与患者的免疫缺陷有关。
