Serova L V, Deriagina S N, Ivanova S Ia, Nosovskiĭ A M
Zh Evol Biokhim Fiziol. 1995 Sep-Dec;31(5-6):611-7.
Female Wistar rats were exposed to stress (water deprivation) during 3 days starting from the 8th, 14th or 19th day of pregnancy. In all cases serious changes in the mother's organism were observed and they were manifested in the essential delay of body mass increment. The main indexes of reproductive function (the number of alive new-born rats, relationship between males and females in broods) did not change. The signs of lagging behind in development were revealed for experimental groups of new-born rats (less body mass, delay of bone formation) and they were the most pronounced in the group exposed to stress at the 14-17th day of pregnancy. In postnatal period no essential differences between experimental groups and control in terms of teeth appearance, hearing onset, as well as in the indexes of physical endurance were observed. Behavioral reactions of progeny in the "open field" appeared to be changed only for the generation of female rats exposed to stress in the second period of pregnancy and were different on the exposures as of the 14-17th and 19th-22nd day of pregnancy. The results obtained have been discussed in the context of views about critical periods of development.
从怀孕第8天、第14天或第19天开始，对雌性Wistar大鼠进行为期3天的应激处理（禁水）。在所有情况下，均观察到母体机体出现严重变化，表现为体重增加明显延迟。生殖功能的主要指标（存活新生大鼠的数量、窝内雌雄比例）未发生变化。新生大鼠实验组出现发育迟缓迹象（体重较轻、骨形成延迟），在怀孕第14 - 17天接受应激处理的组中最为明显。在出生后时期，实验组与对照组在出牙、听力开始时间以及身体耐力指标方面未观察到本质差异。仅在怀孕第二期接受应激处理的雌性大鼠后代在“旷场试验”中的行为反应出现变化，且在怀孕第14 - 17天和第19 - 22天接受应激处理时有所不同。已结合发育关键期的观点对所得结果进行了讨论。
