聚合脂质体的体外稳定性研究
Study on in vitro stability of polymerized liposomes.
作者信息
Nishiya T, Jain B
机构信息
Artificial Cells & Organs Research Centre, McGill University, Montreal, Quebec, Canada.
出版信息
Artif Cells Blood Substit Immobil Biotechnol. 1996 Jan;24(1):43-50. doi: 10.3109/10731199609117430.
We studied the stability of liposomes composed of polymerized phospholipid, 1,2-bis-(octadeca-2,4-dienoyl)-sn-glycero-3-phosphocholine (DENPC), to pH changes and the presence of bile salts, monitoring the leakage of 3H-sucrose entrapped in liposomes. The stability of polymerized DENPC-liposomes to acidic media (pH 3.3 and 2), and the presence of bile salts (20 mM), was much higher than that of nonpolymerized DENPC-liposomes and liposomes composed of conventional phospholipids. The stability of polymerized DENPC-liposomes was increased in the presence of carboxymethyl chitin (CM-chitin).
我们研究了由聚合磷脂1,2-双（十八碳-2,4-二烯酰基）-sn-甘油-3-磷酸胆碱（DENPC）组成的脂质体对pH变化和胆汁盐存在的稳定性，监测包裹在脂质体中的3H-蔗糖的泄漏情况。聚合DENPC脂质体对酸性介质（pH 3.3和2）以及胆汁盐（20 mM）的稳定性远高于未聚合的DENPC脂质体和由传统磷脂组成的脂质体。在羧甲基几丁质（CM-几丁质）存在下，聚合DENPC脂质体的稳定性增强。
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