[Current views on pathophysiology of migraine. Part IV: autonomic disturbances. Central neural hypothesis. Conclusions].

The last part of the article concerns the role of the disturbances of autonomic system and central neural hypothesis of migraine pathogenesis. The author presents the results of studies on pupillometry and autonomic heart regulation, that seem to indicate hypofunction of the autonomic system in migraine. The views on "neurogenic inflammation", as the basic pathologic phenomenon in migraine attack are also discussed, as well as the hypothesis of cortical spreading depression. In the conclusions the author find that neither theory can convincingly explain the pathogenesis of migraine. The updated studies seem to indicate both vascular, autonomic and central neural factors in, possibly multifactorial, pathogenesis of migraine.