母体双侧肾上腺切除及给予外源性糖皮质激素后大鼠胎儿肾上腺皮质的超微结构变化
Ultrastructural variations of the rat fetal adrenal cortex after maternal bilateral adrenalectomy and exogen glucocorticoid administration.
作者信息
Machin C, Sierra J, Diaz B, Rua C
机构信息
Departamento de Biología Celular, Facultad de Biología, Universidad Complutense de Madrid, Spain.
出版信息
Acta Biol Hung. 1995;46(1):87-98.
Rat fetal adrenal cortex ultrastructure was studied in fetuses of 20 days of gestation coming from control (C) pregnant rats and from mothers undergoing two experimental conditions: maternal bilateral adrenalectomy on day 1 of gestation (ADX) and maternal bilateral adrenalectomy plus posterior dexamethasone administration the days 15, 16 and 17 of gestation (A+D). Our results show ultrastructural changes in the ADX rat fetal adrenal cortex, consisting of hyperactive steroidogenical features as response to the absence of maternal glucocorticoids, and the restoration of the control structural characteristics after dexamethasone administration to adrenalectomized animals.
对来自对照（C）妊娠大鼠以及处于两种实验条件下的孕鼠所产胎儿的妊娠20天大鼠胎儿肾上腺皮质超微结构进行了研究：在妊娠第1天进行母体双侧肾上腺切除术（ADX），以及在妊娠第15、16和17天进行母体双侧肾上腺切除术并在后给予地塞米松（A+D）。我们的结果显示，ADX大鼠胎儿肾上腺皮质存在超微结构变化，表现为对母体糖皮质激素缺乏的反应而具有活跃的类固醇生成特征，并且在对肾上腺切除动物给予地塞米松后，其结构特征恢复到对照状态。
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