In some instances, the lay and scientific community already have concluded that antioxidants confer protection against cataracts and macular degeneration, and have been using them toward that end for some years. 2. Because vitamins are not considered drugs, their prescription and dosage are not subject to the regulation of the Food and Drug Administration. While some studies support their use, others do not. 3. Until sound randomized, controlled clinical trials have been completed in the use of antioxidant supplements and the development of cataracts and macular degeneration, the exact therapeutic role and dosage of antioxidants will remain less than clear. As is the case with any drug, short- and long-term side effects, as well as potential toxicity, have to be carefully weighed against the protective benefits in each individual case.