Stokes G S, Graham R M, Gain J M, Davis P R
Br Med J. 1977 Jun 11;1(6075):1507-8. doi: 10.1136/bmj.1.6075.1507.
The effects of the first dose of prazosin were assessed in hypertensive patients on different sodium intakes. Patients received 250, 100, or 30 mmol sodium per 24 hours for a week before taking 2 mg or 0-5 mg prazosin. The acute effects of prazosin on blood pressure and pulse rate were milder with a high sodium intake. On the 100-mmol intake symptomatic postural hypotension occurred in five out of seven patients given 2 mg prazosin and in two out of four given a 0-5-mg dose, whereas those taking 2 mg or 0-5 mg and a 250-mmol sodium intake experienced no postural symptoms. These findings indicate that particular care should be taken in starting prazosin treatment in sodium-depleted patients.
在不同钠摄入量的高血压患者中评估了首剂哌唑嗪的效果。患者在服用2毫克或0.5毫克哌唑嗪之前，先接受为期一周的每日250、100或30毫摩尔钠的摄入。高钠摄入时，哌唑嗪对血压和脉搏率的急性影响较轻微。在摄入100毫摩尔钠时，服用2毫克哌唑嗪的7名患者中有5名出现症状性体位性低血压，服用0.5毫克剂量的4名患者中有2名出现，而服用2毫克或0.5毫克且钠摄入量为250毫摩尔的患者未出现体位症状。这些发现表明，在钠缺乏的患者中开始哌唑嗪治疗时应格外小心。
