Young A, Gilbert J, Sherman M, Chatwin D, Budden J
Br J Nurs. 1996;5(9):539-43. doi: 10.12968/bjon.1996.5.9.539.
A novel carrier solution, icodextrin 20 (7.5%) has allowed exploration of prolonged intraperitoneal (IP) infusion of the cytotoxic drug, 5-fluorouracil. Eighteen patients with intraperitoneal carcinomatosis were entered into a feasibility and pharmacokinetic study of prolonged regional (IP) chemotherapy.. Specialist nurses trained the patients to self-administer their own treatment via a permanent i.p. catheter. A twin bag delivery system was used to perform one exchange daily. It proved possible to deliver continuous (5 days per week) i.p. 5-fluorouracil at doses of 200 mg/m2 and 300 mg/m2 for up to 12 weeks. The toxicities seen were infective peritonitis, nausea and vomiting, lethargy and anorexia. This was a nurse-led study and the home-based therapy holds promise for patients with malignant peritoneal disease.
一种新型载体溶液，即艾考糊精20（7.5%），使得对细胞毒性药物5-氟尿嘧啶进行长时间腹腔内（IP）输注成为可能。18例腹膜癌患者参与了一项关于长时间区域（IP）化疗的可行性和药代动力学研究。专业护士培训患者通过永久性腹腔导管自行给药。采用双袋给药系统，每天进行一次更换。结果证明，以200mg/m²和300mg/m²的剂量连续（每周5天）腹腔内输注5-氟尿嘧啶长达12周是可行的。观察到的毒性反应包括感染性腹膜炎、恶心和呕吐、嗜睡和厌食。这是一项由护士主导的研究，居家治疗对恶性腹膜疾病患者具有前景。
