Nomori H, Horio H, Iga R, Fuyuno G, Kobayashi R, Morinaga S
Department of Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Jan;34(1):76-9.
Palmo-plantar hyperkeratosis (PPH) is a diffuse keratoderma of the palms and soles that has been reported to be associated with internal malignancies such as lung and esophageal carcinomas. When PPH is associated with malignancy the prognosis is poor. The present patient was a 48-year-old man with PPH who suffered from squamous cell carcinoma of the lung. The pathological stage was T4N2M1 and the patient died of recurrent tumor 17 months after surgery. Because the prognosis of lung carcinoma associated with PPH is poor, patients with these conditions should undergo frequent medical examinations, which should include chest radiography and cytologic examination of sputum.
掌跖角化过度症（PPH）是一种手掌和足底的弥漫性角化皮肤病，据报道与肺癌和食管癌等内部恶性肿瘤有关。当PPH与恶性肿瘤相关时，预后较差。本患者为一名48岁患有PPH的男性，患有肺鳞状细胞癌。病理分期为T4N2M1，患者术后17个月死于肿瘤复发。由于与PPH相关的肺癌预后较差，患有这些疾病的患者应经常进行医学检查，包括胸部X线检查和痰细胞学检查。
