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Influence of thyroid hormones on the human ATP synthase beta-subunit gene promoter.

作者信息

Martin I, Villena J A, Giralt M, Iglesias R, Mampel T, Vińas O, Villarroya F

机构信息

Departament de Bioquimica i Fisiologia, Universitat de Barcelona, Spain.

出版信息

Mol Cell Biochem. 1996 Jan 26;154(2):107-11. doi: 10.1007/BF00226778.

DOI:10.1007/BF00226778
PMID:8717424
Abstract

The action of thyroid hormones on the expression of the mitochondrial ATP synthase beta-subunit gene (ATPsyn beta) is controversial. We detected a binding site for the thyroid hormone receptor between -366 and -380 in the human ATPsyn beta gene by DNase I footprint analysis and band-shift assays. However, expression vectors in which the chloramphenicol acetyl transferase (CAT) reporter gene is driven by the 5' upstream region of ATPsyn beta gene were unresponsive to T3 when transiently transfected to HepG2 or GH4C1 cells. CAT constructs driven by the rat phosphoenolpyruvate carboxykinase (PEPCK) or the growth hormone (GH) promoters were stimulated several fold by T3 in parallel experiments. It is proposed that the biological effects of thyroid hormones on the ATPsyn beta expression occur through indirect mechanisms.

摘要

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本文引用的文献

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Thyroid hormones promote transcriptional activation of the nuclear gene coding for mitochondrial beta-F1-ATPase in rat liver.甲状腺激素可促进大鼠肝脏中编码线粒体β-F1-ATP酶的核基因的转录激活。
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