Frati A C, Iniestra F, Ariza C R
Department of Internal Medicine, Hospital de Especialidades del Centro Medico La Raza, Mexico City, Mexico.
Diabetes Care. 1996 Feb;19(2):112-8. doi: 10.2337/diacare.19.2.112.
To investigate the acute effect of cigarette smoking on glucose tolerance, insulin sensitivity, serum lipids, blood pressure, and heart rate.
This nonrandomized experimental control trial in a tertiary care center included 20 healthy chronic smokers and 20 age-, sex-, and BMI-matched healthy volunteers. Two oral glucose tolerance tests (OGTTs) were performed on each subject. Three cigarettes were smoked during the first 30 min in one of the tests. Serum glucose, insulin, and C-peptide levels were measured every 30 min; the area under the curve (AUC) and the insulin sensitivity index (ISI) were calculated; serum total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels were measured at 0 and 180 min; and blood pressure and heart rate were recorded every 5 min throughout 180 min.
Smoking acutely impaired glucose tolerance: the AUC for glucose in smokers was 25.5 +/- 1.03 mmol/l (mean +/- SE) (95% CI 22.9-28) during the smoking OGTT and 21.8 +/- 0.85 mmol/l (CI 19.2-24.3) in the control OGTT (P < 0.01); in nonsmokers, it was 19.7 +/- 0.3 mmol/l (CI 18.8-20.5) in the smoking OGTT and 18.7 +/- 0.35 mmol/l (CI 17.8-19.5) in the control OGTT (P < 0.05). Smoking acutely increased serum insulin and C-peptide levels and decreased ISI only in smokers: ISI in smokers was 55 +/- 2.8 (CI 47.4-62.6) in the control OGTT and 43 +/- 2.7 (CI 35.4-50.6) in the smoking OGTT (P < 0.05). Smoking acutely caused a rise of serum total cholesterol levels in both groups and increased LDL cholesterol and triglyceride serum levels significantly only in smokers (P < 0.05). A significant rise of blood pressure and heart rate while smoking was present in all the subjects.
Smoking acutely impaired glucose tolerance and insulin sensitivity, enhanced serum cholesterol and triglyceride levels, and raised blood pressure and heart rate. These findings support the pathogenetic role of cigarette smoking on cardiovascular risk factors.
探讨吸烟对葡萄糖耐量、胰岛素敏感性、血脂、血压和心率的急性影响。
这项在三级医疗中心进行的非随机实验对照试验纳入了20名健康的慢性吸烟者和20名年龄、性别及体重指数相匹配的健康志愿者。对每位受试者进行两次口服葡萄糖耐量试验（OGTT）。在其中一次试验的前30分钟内让受试者吸3支烟。每30分钟测量血清葡萄糖、胰岛素和C肽水平；计算曲线下面积（AUC）和胰岛素敏感性指数（ISI）；在0分钟和180分钟时测量血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯水平；在整个180分钟内每5分钟记录一次血压和心率。
吸烟急性损害葡萄糖耐量：吸烟者在吸烟OGTT期间葡萄糖的AUC为25.5±1.03 mmol/l（均值±标准误）（95%置信区间22.9 - 28），在对照OGTT中为21.8±0.85 mmol/l（置信区间19.2 - 24.3）（P<0.01）；在不吸烟者中，吸烟OGTT时为19.7±0.3 mmol/l（置信区间18.8 - 20.5），对照OGTT时为18.7±0.35 mmol/l（置信区间17.8 - 19.5）（P<0.05）。吸烟仅在吸烟者中急性增加血清胰岛素和C肽水平并降低ISI：吸烟者在对照OGTT中的ISI为55±2.8（置信区间47.4 - 62.6），在吸烟OGTT中为43±2.7（置信区间35.4 - 50.6）（P<0.
