Abildskov J A
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, USA.
J Cardiovasc Electrophysiol. 1996 Jan;7(1):71-81. doi: 10.1111/j.1540-8167.1996.tb00462.x.
A previous communication in the Creative Musings section of this Journal summarized additions to the wavelet hypothesis related to the initiation of cardiac fibrillation. That hypothesis is also relevant to the termination of fibrillation, and further additions related to that event are presented in this report. Findings in both reports were obtained with a computer model based on the wavelet hypothesis, and results concerning initiation and termination of fibrillation were closely related. Refractory period (RP) conditions that terminated fibrillation were the inverse of those that increased vulnerability to the initiation of fibrillation. Increased RP range or decreased RP duration increased vulnerability to the initiation of fibrillation and decreased RP range or increased RP duration were capable of terminating fibrillation. Slow propagation increased vulnerability to initiation of fibrillation and acted to sustain fibrillation when instituted during fibrillation. The combination of increased duration and decreased range of RPs was more effective in terminating fibrillation than either alone. The magnitude of increased RP duration or decreased RP range required to terminate fibrillation and the effects of slow propagation on the maintenance of fibrillation depended on RP duration and range present during fibrillation. The findings extend the wavelet hypothesis of the nature of fibrillation to the prediction of conditions required to terminate fibrillation.
本期刊“创意漫谈”版块之前的一篇通讯总结了与房颤起始相关的小波假说的补充内容。该假说也与房颤的终止有关，本报告将介绍与该事件相关的进一步补充内容。两份报告中的研究结果均通过基于小波假说的计算机模型获得，且有关房颤起始和终止的结果密切相关。终止房颤的不应期（RP）条件与增加房颤起始易感性的条件相反。增加RP范围或缩短RP持续时间会增加房颤起始的易感性，而减小RP范围或延长RP持续时间则能够终止房颤。缓慢传导增加了房颤起始的易感性，并在房颤期间出现时起到维持房颤的作用。RP持续时间增加和范围减小相结合在终止房颤方面比单独任何一种情况都更有效。终止房颤所需的RP持续时间增加或范围减小的幅度以及缓慢传导对房颤维持的影响取决于房颤期间存在的RP持续时间和范围。这些发现将房颤本质的小波假说扩展到对终止房颤所需条件的预测。
