Krauss T, Rath W, Cunze T
Universitäts-Frauenklinik Göttingen.
Geburtshilfe Frauenheilkd. 1994 Nov;54(11):623-6. doi: 10.1055/s-2007-1022353.
In a prospective study termination of pregnancy was performed between the 16th and 24th week of gestation by serial applications of a 1 mg gemeprost containing vaginal pessary at 6h intervals. The reasons for termination were medical and fetal indications in 20 cases and missed abortion in 14 cases. The median induction to abortion interval was 17.4 hours (range: 3.7 - 73.0h) in the therapeutic abortion group, and a median of 3 applications were necessary to terminate pregnancy. In cases of missed abortion the median induction to abortion intervals was 11.0h (range: 3.5 - 32.5h) with a median of 2 necessary applications. Expulsion of the fetus occurred in 31 out of 34 patients (91.2%) within 24 hours. Spontaneous or surgically induced cervical lesions and blood loss > 500 ml were not observed, systemic prostaglandin-induced side effects were documented in 7 cases (20.6%). Epidural anesthetic gave a painless induction of abortion in all of patients. Our experience has shown that serial application of gemeprost vaginal pessaries is a feasible and efficient method for termination of second trimester pregnancies.
在一项前瞻性研究中，于妊娠第16至24周期间，通过每隔6小时连续应用含1毫克吉美前列素的阴道栓剂来终止妊娠。终止妊娠的原因中，20例为医学及胎儿指征，14例为稽留流产。治疗性流产组中，引产至流产的间隔时间中位数为17.4小时（范围：3.7 - 73.0小时），终止妊娠平均需要3次用药。稽留流产病例中，引产至流产间隔时间中位数为11.0小时（范围：3.5 - 32.5小时），平均需要2次用药。34例患者中有31例（91.2%）在24小时内排出胎儿。未观察到自发性或手术引起的宫颈损伤及失血>500毫升的情况，有7例（20.6%）记录到全身性前列腺素引起的副作用。所有患者均通过硬膜外麻醉实现无痛引产。我们的经验表明，连续应用吉美前列素阴道栓剂是中期妊娠终止的一种可行且有效的方法。
