促性腺激素释放激素（GnRH）受体的信号转导：钙、蛋白激酶C（PKC）和花生四烯酸的相互作用
Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: cross-talk of calcium, protein kinase C (PKC), and arachidonic acid.
作者信息
Naor Z, Shacham S, Harris D, Seger R, Reiss N
机构信息
Department of Biochemistry, Tel Aviv University, Ramat Aviv, Israel.
出版信息
Cell Mol Neurobiol. 1995 Oct;15(5):527-44. doi: 10.1007/BF02071315.
Abstract
- The decapeptide neurohormone gonadotropin releasing hormone (GnRH) is the first key hormone of the reproductive system. Produced in the hypothalamus, GnRH is released in a pulsatile manner into the hypophysial portal system to reach the anterior pituitary and stimulates the release and synthesis of the gonadotropin hormones LH and FSH. GnRH, a Ca2+ mobilizing ligand, binds to its respective binding protein, which is a member of the seven transmembrane domain receptor family and activates a G-protein (Gq). 2. The alpha subunit of Gq triggers enhanced phosphoinositide turnover and the elevation of multiple second messengers required for gonadotropin release and biosynthesis. 3. The messenger molecules IP3, diacylglycerol, Ca2+, protein kinase C, arachidonic acid and leukotriene C4 cross-talk in a complex networks of signaling, culminating in gonadotropin release and gene expression.
摘要
- 十肽神经激素促性腺激素释放激素（GnRH）是生殖系统的首个关键激素。GnRH在下丘脑产生，以脉冲方式释放到垂体门脉系统，到达垂体前叶，刺激促性腺激素LH和FSH的释放与合成。GnRH是一种可动员Ca2+的配体，与其相应的结合蛋白结合，该结合蛋白是七跨膜结构域受体家族的成员，并激活G蛋白（Gq）。2. Gq的α亚基引发磷酸肌醇代谢增强以及促性腺激素释放和生物合成所需的多种第二信使水平升高。3. 信使分子肌醇三磷酸（IP3）、二酰甘油、Ca2+、蛋白激酶C、花生四烯酸和白三烯C4在复杂的信号网络中相互作用，最终导致促性腺激素释放和基因表达。
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