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Mash-1在视杆光感受器分化过程中表达，并与大鼠视蛋白基因中的一个E盒E(视蛋白)-1结合。

Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, E(opsin)-1 in the rat opsin gene.

作者信息

Ahmad I

机构信息

Department of Cell Biology and Anatomy and Ophthalmology, University of Nebraska Medical Center, Omaha 68198, USA.

出版信息

Brain Res Dev Brain Res. 1995 Dec 21;90(1-2):184-9. doi: 10.1016/0165-3806(96)83500-0.

DOI:10.1016/0165-3806(96)83500-0
PMID:8719343
Abstract

It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.

摘要

先前的研究表明，转录因子Mash-1在哺乳动物神经发生中起重要作用。在本研究中，我们发现Mash-1在大鼠视网膜发育过程中表达，并且在视杆光感受器分化过程中，它与视蛋白基因启动子中鉴定出的一个E盒特异性相互作用。我们提出，视蛋白可能是中枢神经系统神经发生过程中受Mash-1调控的下游神经元基因之一。

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