Kristjansson A, Grubb A, Månsson W
Department of Urology, University Hospital, Lund, Sweden.
Scand J Urol Nephrol. 1995 Dec;29(4):407-12. doi: 10.3109/00365599509180021.
Renal tubular function can be assessed by measuring low molecular weight proteins in urine. In the present study, urinary levels of protein HC, also called alpha 1-microglobulin, were determined in 84 patients, 3-17 years after conduit diversion or continent urinary reconstruction. Increased excretion of protein HC, indicating tubular dysfunction, was found in 30 patients (36%), but was slight in most cases. Among patients with GFR > 45 ml/min/1.73 m2 at latest follow-up, the fall from preoperative GFR was greater in those with elevated levels of protein HC than in those with normal levels (p < 0.01). No permeation of protein HC through the intestinal mucosa in contact with urine could be demonstrated. Urinary protein HC may be a suitable marker for detecting early renal impairment after urinary diversion.
肾小管功能可通过测量尿液中的低分子量蛋白质来评估。在本研究中，对84例患者进行了导尿改道或可控性尿流改道术后3至17年的尿蛋白HC（也称为α1-微球蛋白）水平测定。30例患者（36%）出现蛋白HC排泄增加，提示肾小管功能障碍，但大多数情况下程度较轻。在最新随访时肾小球滤过率（GFR）>45 ml/min/1.73 m2的患者中，蛋白HC水平升高者术前GFR的下降幅度大于水平正常者（p<0.01）。未证实蛋白HC透过与尿液接触的肠黏膜。尿蛋白HC可能是检测尿流改道后早期肾功能损害的合适标志物。
