Vatne V, Maartmann-Moe H, Hoestmark J
Dept. of Surgery, Gade Institute, Haukeland University Hospital, Bergen, Norway.
Scand J Urol Nephrol. 1995 Dec;29(4):491-5. doi: 10.3109/00365599509180032.
Approximately 1/3 of T1 bladder cancers treated by endoscopic resection alone will progress. Prognostic factors are needed to help selecting appropriate treatment for these tumors. The purpose of the present investigation was to study the relation between p53 nuclear overexpression and disease progression. Tumors from 59 patients were studied by means of immunohistochemical nuclear staining. Forty tumors showed p53 nuclear overexpression while 19 tumors scored negative for mutations. We could not demonstrate any correlation between mutations of the p53 protein and tumor grading. p53 nuclear overexpression was not related to disease progression.
仅接受内镜切除治疗的T1期膀胱癌约有1/3会进展。需要预后因素来帮助为这些肿瘤选择合适的治疗方法。本研究的目的是探讨p53核过表达与疾病进展之间的关系。通过免疫组化核染色研究了59例患者的肿瘤。40个肿瘤显示p53核过表达，而19个肿瘤p53蛋白突变检测为阴性。我们未能证实p53蛋白突变与肿瘤分级之间存在任何相关性。p53核过表达与疾病进展无关。
