Godsiff L, Magee L, Park G R
John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
Eur J Anaesthesiol Suppl. 1995 Nov;12:35-40.
We evaluated the addition of midazolam to propofol during induction of anaesthesia by assessing laryngeal mask tolerance, haemodynamic variables, recovery times and cost. Forty patients (ASA grades I-IV) undergoing elective surgery were allocated randomly to receive a standard dose of propofol or a smaller dose of propofol combined with midazolam. A laryngeal mask was inserted and any episodes of coughing or hiccuping during its insertion or removal were recorded. Anaesthesia was maintained with nitrous oxide and enflurane with fentanyl for analgesia. After surgery, recovery times, pain, shivering, nausea, vomiting and analgesic requirements were recorded. The cost of the drugs used was also calculated. No significant differences were detected in any variables, except that patients given propofol needed more morphine in the recovery ward. The average cost of propofol alone was 3.47 pounds per anaesthetic, while the midazolam plus propofol cost was 2.03 pounds. Adding midazolam to propofol allowed a reduced dose of propofol to be used without adverse effects, while reducing the anaesthetic costs.
我们通过评估喉罩耐受性、血流动力学变量、恢复时间和成本，来研究在麻醉诱导期间丙泊酚中加入咪达唑仑的效果。40例（ASA分级I-IV级）择期手术患者被随机分配接受标准剂量丙泊酚或小剂量丙泊酚联合咪达唑仑。插入喉罩，并记录插入或移除喉罩期间的任何咳嗽或打嗝发作。使用氧化亚氮和恩氟烷维持麻醉，并使用芬太尼镇痛。术后记录恢复时间、疼痛、寒战、恶心、呕吐和镇痛需求。还计算了所用药物的成本。除了在恢复病房接受丙泊酚的患者需要更多吗啡外，未在任何变量中检测到显著差异。单独使用丙泊酚的平均成本为每次麻醉3.47英镑，而咪达唑仑加丙泊酚的成本为2.03英镑。在丙泊酚中加入咪达唑仑可减少丙泊酚的使用剂量而无不良影响，同时降低麻醉成本。
