Luks F I, Gilchrist B F, Jackson B T, Piasecki G J
Department of Surgery, Brown University School of Medicine, Providence, RI 02903, USA.
Fetal Diagn Ther. 1996 Jan-Feb;11(1):67-71. doi: 10.1159/000264282.
Tracheal obstruction to promote lung growth may be a less aggressive alternative to open fetal surgery in the antenatal treatment of congenital diaphragmatic hernia. Herein, we explore the feasibility of placing an occluding device through fetal tracheoscopy. A self-expanding umbrella allowed adequate sealing of the tracheal lumen even as the tracheal diameter more than doubled between 110 and 138 days of gestation (term = 145 days) in a sheep model. Distal intratracheal pressures after umbrella placement, and lung weight at delivery, were comparable to those after formal tracheal ligation.
在先天性膈疝的产前治疗中，气管阻塞促进肺生长可能是一种比开放性胎儿手术侵入性更小的替代方法。在此，我们探讨通过胎儿气管镜放置阻塞装置的可行性。在绵羊模型中，一种自膨胀伞即使在妊娠110至138天（足月为145天）期间气管直径增加一倍多的情况下，也能充分密封气管腔。放置伞后气管远端压力以及分娩时肺重量与正式气管结扎后的情况相当。
