Shindo K, Nagasaka T, Tsunoda S, Shiozawa Z
Third Department of Internal Medicine, Yamanashi Medical College, Japan.
Rinsho Shinkeigaku. 1995 Nov;35(11):1179-83.
Muscle sympathetic nerve activity (MSNA) was compared in 6 patients (age; 45-76 years old, 3 males and 3 females) with spinocerebellar degeneration (SCD) without orthostatic hypotension (OH) and in 10 (age; 38-78 years old, 3 males and 7 females) with other neurologic disorders (controls). MSNA was elicited from the peroneal nerve at the resting recumbent position by using a microneurographic method. MSNA, heart rate (HR) from the electrocardiogram and mean blood pressure (MBP) measured by Finapres were recorded simultaneously at rest and during the head-up tilting at 45 degrees. Although there were no significant differences in MBP and HR between both groups, burst rate (bursts per minute) and burst incidence (bursts per 100 heart beats) of MSNA in SCD patients were significantly decreased as compared with controls (p < 0.01). During the head-up tilting, responses in MBP and MSNA showed a tendency to decrease in SCD patients. We concluded that the sympathetic noradrenergic system might be potentially impaired in SCD patients without OH.
对6例（年龄45 - 76岁，3男3女）无体位性低血压（OH）的脊髓小脑变性（SCD）患者和10例（年龄38 - 78岁，3男7女）患有其他神经系统疾病的患者（对照组）的肌肉交感神经活动（MSNA）进行了比较。通过微神经图法在静卧位从腓总神经引出MSNA。在静息状态和45度头高位倾斜期间，同时记录通过微神经图法从腓总神经引出的MSNA、心电图测得的心率（HR）以及Finapres测量的平均血压（MBP）。虽然两组间MBP和HR无显著差异，但与对照组相比，SCD患者的MSNA爆发率（每分钟爆发次数）和爆发发生率（每100次心跳爆发次数）显著降低（p < 0.01）。在头高位倾斜期间，SCD患者的MBP和MSNA反应呈下降趋势。我们得出结论，在无OH的SCD患者中，交感去甲肾上腺素能系统可能存在潜在损害。
