Lilien M R, Donckerwolcke R A, Vroom T M
Afd. Kindernefrologie, Universiteitskliniek Wilhelmina Kinderziekenhuis, Utrecht.
Ned Tijdschr Geneeskd. 1996 Feb 10;140(6):316-9.
In three patients, two boys of 7 and 10 and a girl of 9 years old, a kidney disease was diagnosed which evolved from Schönlein-Henoch nephritis to IgA nephropathy or Berger's disease. These two kidney diseases show striking similarities in pathological and immunological respects. Several patients have been described in the literature who suffered from both clinical pictures consecutively and of families in which different members showed either one or the other disease. A remarkable finding was the persistence of an elevated IgA serum level in all three children after the Schönlein-Henoch nephritis had subsided. These cases show the importance of long-term follow up of patients who had Schönlein-Henoch nephritis, in order to diagnose late renal complications at an early stage. They also give more evidence in favour of the assumption that Schönlein-Henoch nephritis and IgA nephropathy have a common aetiology.
在三名患者中，分别是两名7岁和10岁的男孩以及一名9岁的女孩，他们被诊断出患有一种肾脏疾病，该疾病从过敏性紫癜肾炎发展为IgA肾病或伯杰氏病。这两种肾脏疾病在病理和免疫学方面表现出惊人的相似性。文献中描述了几名患者先后患有这两种临床表现，以及一些家庭中不同成员分别患有其中一种疾病的情况。一个显著的发现是，在过敏性紫癜肾炎消退后，所有三名儿童的血清IgA水平持续升高。这些病例表明，对患有过敏性紫癜肾炎的患者进行长期随访非常重要，以便早期诊断晚期肾脏并发症。它们也为过敏性紫癜肾炎和IgA肾病具有共同病因这一假设提供了更多证据。
