Tomino Y, Endoh M, Suga T, Miura M, Kaneshige H, Nomoto Y, Sakai H
Tokai J Exp Clin Med. 1982 Jul;7(4):527-32.
A study on the detection of IgA1, IgA2 and the J("joining") chain in glomeruli from renal biopsy specimens in patients with Henoch-Schoenlein purpura (HSP) nephritis is described. Renal biopsy specimens from five patients with HSP nephritis were stained with FITC-labelled anti-human IgA1, IgA2 and J chain, and then examined with a fluorescent microscope. IgA1 was detected in glomeruli from all patients with HSP nephritis examined in this study. IgA2 was not observed in any patients. These findings were similar to those for IgA nephropathy reported previously. Histopathological findings of glomeruli in HSP nephritis were almost identical to those in IgA nephropathy. The levels of serum IgA in patients with HSP nephritis increased as observed in IgA nephropathy. It is suggested that there are some immunopathological similarities between HSP nephritis and IgA nephropathy.
本文描述了一项关于检测过敏性紫癜（HSP）肾炎患者肾活检标本肾小球中IgA1、IgA2和J（连接）链的研究。对5例HSP肾炎患者的肾活检标本用异硫氰酸荧光素（FITC）标记的抗人IgA1、IgA2和J链进行染色，然后用荧光显微镜检查。在本研究中检测的所有HSP肾炎患者的肾小球中均检测到IgA1。在任何患者中均未观察到IgA2。这些发现与先前报道的IgA肾病的发现相似。HSP肾炎肾小球的组织病理学发现与IgA肾病几乎相同。HSP肾炎患者的血清IgA水平如在IgA肾病中观察到的那样升高。提示HSP肾炎与IgA肾病之间存在一些免疫病理学相似性。
