Nasr N T, Bodghdadi A M, Allam K A, El-Adawi A I, Soliman M I
Department of Parasitology, Cairo University and Research Institute of Medical Entomology, Egypt.
J Egypt Soc Parasitol. 1996 Apr;26(1):161-8.
The effect of two different doses of ivermectin on the survival and fecundity of Culex pipiens was evaluated. Female mosquitoes (50 in each group), same age and generation, were fed once on blood from ivermectin-treated rabbits. Comparative treatments consisted of two different doses of ivermectin (0.1 mg or 0.4 mg/kg of body weight), and mosquito groups were fed on the rabbits at 3 days and 10 days post-treatment respectively. Mosquitoes were maintained with 10% sucrose solution, at 25 degrees C and 70% relative humidity. Observations were made at 7, 10, 15, 20, 25, and 30 days post-feeding. Mosquitoes fed on rabbits treated with the small dose at three days post-injection showed reduced survival of 94%, 62%, 44%, 8% and 0%, while the 0.4 while the 0.4 mg/kg of body weight (bw) dose reduced survival to 88%, 60%, 6% and 0%. Survival of the control groups were 100%, 90%, 88%, 68% and 52% respectively. Survival of adult females fed at the lower dose, 10 days post injection were reduced to 92%, 90%, 84% 60% and 44%; while the higher dose reduced survival to 86%, 58%, 34% 22% and 0%. Survival of control groups were 96%, 92%, 84%, 78% and 72% respectively. Fecundity resulting from blood meals at 3 and 10 days post injection were 61% and 85% for the lower dose, and 0% and 42% for the higher dose respectively. Hatching of eggs was 82% and 88% for the 0.1 mg/kg bw dose, and no hatching was observed at the higher dose. Larval survival rates resulting from blood meals taken 3 days and 10 days post-injection of the lower dose were 24% and 25% respectively. However, no larvae survived from the high dose groups. Larval survival rates in control groups were 42% and 40%, respectively. These results provide new information about the effect of ivermectin on the vector of lymphatic filariasis, and add a new dimension to the use of ivermectin in filariasis control.
评估了两种不同剂量的伊维菌素对致倦库蚊存活和繁殖力的影响。选取年龄和世代相同的雌性蚊子（每组50只），让它们吸食一次经伊维菌素处理的兔子的血液。对照处理包括两种不同剂量的伊维菌素（0.1毫克或0.4毫克/千克体重），蚊子组分别在处理后3天和10天吸食兔子血液。蚊子用10%的蔗糖溶液饲养，温度为25摄氏度，相对湿度为70%。在喂食后7、10、15、20、25和30天进行观察。注射后3天吸食小剂量处理兔子血液的蚊子，存活率分别降低至94%、62%、44%、8%和0%，而0.4毫克/千克体重剂量的蚊子存活率降低至88%、60%、6%和0%。对照组的存活率分别为100%、90%、88%、68%和52%。注射后10天吸食低剂量血液的成年雌性蚊子存活率分别降低至92%、90%、84%、60%和44%；而高剂量组存活率降低至86%、58%、34%、22%和0%。对照组的存活率分别为96%、92%、84%、78%和72%。注射后3天和10天吸食血液后的繁殖力，低剂量组分别为61%和85%，高剂量组分别为0%和42%。0.1毫克/千克体重剂量组的卵孵化率为82%和88%，高剂量组未观察到孵化现象。注射后3天和10天吸食低剂量血液后的幼虫存活率分别为24%和25%。然而，高剂量组没有幼虫存活。对照组的幼虫存活率分别为42%和40%。这些结果提供了关于伊维菌素对淋巴丝虫病传播媒介影响的新信息，并为伊维菌素在丝虫病防治中的应用增添了新的维度。
