Hubálek Z, Pow I, Reid H W, Hussain M H
Institute of Ecology, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
Acta Virol. 1995 Dec;39(5-6):251-6.
Twenty isolates of Central European encephalitis (CEE) virus were compared with 20 isolates of louping-ill (LI) virus in indirect immunofluorescence test (IIFT), using a panel of 17 monoclonal antibodies (MoAbs) prepared against the prototype LI virus. Three Asian members of the tick-borne encephalitis (TBE) complex were also included in the comparison: Turkish sheep encephalitis (TSE), Russian spring-summer encephalitis (RSSE) and Langat (LGT) viruses. Antigenic relationships of the viruses were evaluated by Dice similarity coefficient and cluster analysis. The results revealed antigenic heterogeneity of LI isolates, antigenic homogeneity of CEE isolates, and indicated that CEE and LI are related varieties of Eurasian TBE flavivirus that also includes TSE and RSSE strains.
在间接免疫荧光试验（IIFT）中，使用针对原型卢平病（LI）病毒制备的17种单克隆抗体（MoAb），将20株中欧脑炎（CEE）病毒与20株卢平病（LI）病毒进行了比较。蜱传脑炎（TBE）复合体的三个亚洲成员也被纳入比较：土耳其绵羊脑炎（TSE）、俄罗斯春夏脑炎（RSSE）和兰加特（LGT）病毒。通过戴斯相似系数和聚类分析评估了这些病毒的抗原关系。结果显示LI分离株具有抗原异质性，CEE分离株具有抗原同质性，并表明CEE和LI是欧亚TBE黄病毒的相关变种，该病毒还包括TSE和RSSE毒株。
