Borg P A, Krijnen H J
Department of Anaesthesiology, Academic Hospital Groningen, The Netherlands.
Clin J Pain. 1996 Mar;12(1):63-8. doi: 10.1097/00002508-199603000-00012.
To determine the clinical usefulness of the long-term intrathecal administration of midazolam and clonidine in patients with refractory neurogenic and musculoskeletal pain.
Pain Centre, Academic Hospital Groningen, Groningen, The Netherlands.
Four patients with chronic benign neurogenic and musculoskeletal pain, not responding to conventional analgesic therapy. OUTCOME-MEASURES: Visual Analogue Score, Activities of Daily Living.
The intrathecal administration of midazolam and clonidine produced almost immediate and nearly complete pain relief. Even with continuous use, tolerance seemed to be no problem, and side effects appear to be minimal.
Intrathecal infusion of midazolam and clonidine produced promising results in four patients with refractory chronic benign pain. Further research will be necessary to determine the efficacy and the risk-to-benefit ratio of long-term administration of this combination.
确定长期鞘内注射咪达唑仑和可乐定对难治性神经源性和肌肉骨骼疼痛患者的临床疗效。
荷兰格罗宁根学术医院疼痛中心。
4例慢性良性神经源性和肌肉骨骼疼痛患者，对传统镇痛治疗无效。
视觉模拟评分、日常生活活动能力。
鞘内注射咪达唑仑和可乐定几乎能立即产生近乎完全的疼痛缓解。即使持续使用，耐受性似乎也不成问题，且副作用似乎极小。
鞘内输注咪达唑仑和可乐定对4例难治性慢性良性疼痛患者产生了有希望的结果。需要进一步研究以确定长期使用该联合用药的疗效和风险效益比。
