Robinson K A, Roubin G S, King S B
Emory University School of Medicine, Atlanta, Georgia, USA.
Cathet Cardiovasc Diagn. 1996 May;38(1):32-7. doi: 10.1002/(SICI)1097-0304(199605)38:1<32::AID-CCD8>3.0.CO;2-4.
Prosthetic intracoronary stenting has become an important adjunct to balloon angioplasty in the percutaneous treatment of coronary artery disease. However, there are few reports of the long-term histologic consequences of stenting in the world literature. We report the arteriographic, histologic, and ultrastructural examination of a flexible tantalum wire coil stent implanted in the coronary artery of a dog for 7 years. The vessel was arteriographically patent without evidence of either stenosis or ectasia. The stent had been incorporated into the arterial wall, and was covered with a neointima of approximately 100 microns maximum thickness. There was necrosis of the tunica media adjacent to the stent but the inflammatory response was restricted to occasional macrophages in the neointima of the immediate vicinity of the stent wire. The endothelial cell layer was normal in its morphologic appearance. In summary, the flexible tantalum wire coil stent was well tolerated by the host blood vessel and demonstrated acceptable biocompatibility for the 7-year duration of its implantation in the normal dog coronary artery.
在经皮冠状动脉疾病治疗中，冠状动脉内植入支架已成为球囊血管成形术的重要辅助手段。然而，世界文献中关于支架长期组织学后果的报道很少。我们报告了一只犬冠状动脉内植入柔性钽丝线圈支架7年的血管造影、组织学和超微结构检查结果。血管造影显示血管通畅，无狭窄或扩张迹象。支架已融入动脉壁，表面覆盖着最大厚度约100微米的新生内膜。支架相邻的中膜有坏死，但炎症反应仅限于支架丝紧邻区域新生内膜中的偶尔出现的巨噬细胞。内皮细胞层形态外观正常。总之，柔性钽丝线圈支架在正常犬冠状动脉中植入7年期间，宿主血管对其耐受性良好，显示出可接受的生物相容性。
