Schwabe J W
Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Curr Biol. 1996 Apr 1;6(4):372-4. doi: 10.1016/s0960-9822(02)00498-0.
The recently determined structures of the ligand-binding domains from three nuclear receptors show that a receptor undergoes a significant conformational change on ligand binding. It is not yet clear how this structural change results in transcriptional activation.
