Cervenka L, Heller J
Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Ren Fail. 1996 Mar;18(2):173-80. doi: 10.3109/08860229609052787.
The beneficial effects of a low-protein diet vs. angiotensin-converting enzyme inhibitor (ACEI, enalapril) on the course of ablation nephropathy (5/6 nephrectomy, 5/6NX) were compared in a new strain of genetic hypertensive rats, the Prague hypertensive rat (PHR). Both maneuvers were followed by a significant drop in proteinuria (1.27 and 8.8 vs. 56.2 mg/24 hod, p < 0.001, low-protein diet vs. ACEI vs. untreated), plasma levels of creatinine (175.3 and 177.1 vs. 245.3 mumol/L, p < 0.001) and urea (7.95 and 13.51 vs. 37.6 mmol/L, p < 0.001). Endogenous creatinine clearance was higher after both low-protein diet and ACEI than without them (134.6 and 127.8 vs. 56.7 microL/min/100 g BW, p < 0.001). Both maneuvers had a similar beneficial effect: no additional amelioration was observed with a combination of both low-protein diet and ACEI. Compared to normotensive Wistar rats, the results were quite similar in PHR except the blood pressure values; hypertension had no substantial effect on the course of 5/6NX or on the beneficial action of both low-protein diet and ACEI.
在一种新的遗传性高血压大鼠品系——布拉格高血压大鼠（PHR）中，比较了低蛋白饮食与血管紧张素转换酶抑制剂（ACEI，依那普利）对切除性肾病（5/6肾切除，5/6NX）病程的有益影响。两种处理后蛋白尿均显著下降（低蛋白饮食组与ACEI组与未处理组分别为1.27和8.8 vs. 56.2 mg/24小时，p<0.001），血浆肌酐水平（175.3和177.1 vs. 245.3 μmol/L，p<0.001）和尿素水平（7.95和13.51 vs. 37.6 mmol/L，p<0.001）也显著下降。低蛋白饮食和ACEI处理后内源性肌酐清除率均高于未处理组（134.6和127.8 vs. 56.7 μL/min/100 g体重，p<0.001）。两种处理具有相似的有益效果：低蛋白饮食与ACEI联合使用未观察到额外改善。与正常血压的Wistar大鼠相比，PHR的结果除血压值外相当相似；高血压对5/6NX病程或低蛋白饮食和ACEI的有益作用均无实质性影响。
