对尿毒症患者在血液透析即刻及24小时后进行评估的红细胞核苷酸和血液次黄嘌呤水平。
Erythrocyte nucleotides and blood hypoxanthine in patients with uremia evaluated immediately and 24 hours after hemodialysis.
作者信息
Bułło B, Marlewski M, Smoleński R T, Rutkowski B, Swierczyński J, Manitius J
机构信息
Department of Nephrology, Medical University of Gdansk, Poland.
出版信息
Ren Fail. 1996 Mar;18(2):247-52. doi: 10.3109/08860229609052794.
Using high-performance liquid chromatography, concentrations of erythrocyte adenine nucleotides and hypoxanthine were evaluated in patients undergoing regular acetate hemodialysis before dialysis, immediately following dialysis, and 24 hr after. It was shown that adenosine triphosphate concentration was maintained consistently high, not only just after hemodialysis but also 24 hr later. There was also no difference in concentration of mono- and diphosphates of adenosine. Hypoxanthine concentration decreased twofold after hemodialysis. However, it was still markedly higher than normal values. The level of hypoxanthine was maintained at the postdialysis level, 24 hr later. This suggests that hypoxanthine production could be stimulated during acetate dialysis.
采用高效液相色谱法，对接受常规醋酸盐血液透析的患者在透析前、透析结束即刻以及透析后24小时的红细胞腺嘌呤核苷酸和次黄嘌呤浓度进行了评估。结果显示，三磷酸腺苷浓度不仅在血液透析刚结束后持续保持在较高水平，而且在24小时后依然如此。腺苷一磷酸和二磷酸的浓度也没有差异。血液透析后次黄嘌呤浓度降低了两倍。然而，其仍显著高于正常值。24小时后，次黄嘌呤水平维持在透析后的水平。这表明在醋酸盐透析过程中，次黄嘌呤的生成可能受到了刺激。
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