Jacobson S H, Moldéus P
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Clin Nephrol. 1994 Sep;42(3):189-92.
There are conflicting results regarding the activity of glutathione (GSH) in patients with kidney disease. We examined whole blood-, plasma- and erythrocyte concentrations of GSH and cysteine in 12 patients with renal disease and in 14 patients on maintenance hemodialysis. Total plasma GSH concentrations were higher in patients with kidney disease than in patients maintained on hemodialysis (23.5 +/- 13.1 vs 9.1 +/- 7.5 mumol/l, p < 0.01) but erythrocyte concentrations of GSH were similar. Whole blood-, plasma and erythrocyte concentrations of GSH remained stable during hemodialysis. The total concentration of cysteine in plasma was significantly higher in patients on hemodialysis (556 +/- 258 mumol/l) as compared to patients with kidney disease (248 +/- 53 mumol/l, p < 0.001) but red blood cell concentrations were similar. Whole blood- and plasma concentrations of cysteine decreased significantly during hemodialysis. There were no significant correlations between serum creatinine and GSH or cysteine concentrations in patients on hemodialysis but when all patients were evaluated together, a significant correlation between serum creatinine and total plasma cysteine concentrations was observed (r = 0.52, p = 0.0017).
关于肾病患者体内谷胱甘肽（GSH）的活性，研究结果存在矛盾。我们检测了12例肾病患者和14例维持性血液透析患者全血、血浆及红细胞中GSH和半胱氨酸的浓度。肾病患者的血浆总GSH浓度高于维持性血液透析患者（23.5±13.1 vs 9.1±7.5μmol/L，p<0.01），但红细胞中GSH浓度相似。血液透析过程中，全血、血浆及红细胞中的GSH浓度保持稳定。血液透析患者血浆中的半胱氨酸总浓度（556±258μmol/L）显著高于肾病患者（248±53μmol/L，p<0.001），但红细胞中的浓度相似。血液透析过程中，全血和血浆中的半胱氨酸浓度显著降低。血液透析患者的血清肌酐与GSH或半胱氨酸浓度之间无显著相关性，但当对所有患者进行综合评估时，观察到血清肌酐与血浆总半胱氨酸浓度之间存在显著相关性（r=0.52，p=0.0017）。
