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The precipitate formed by thiopentone and vecuronium.

作者信息

Taniguchi T, Yamamoto K, Kobayashi T

机构信息

Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Japan.

出版信息

Can J Anaesth. 1996 May;43(5 Pt 1):511-3. doi: 10.1007/BF03018114.

DOI:10.1007/BF03018114
PMID:8723859
Abstract

PURPOSE

To determine the composition and solubility of the precipitate formed by thiopentone and vecuronium in vitro.

METHODS

The precipitate formed by mixing thiopentone 2.5% and vecuronium 0.1% at room temperature was analyzed by ultraviolet spectrophotometry and high performance liquid chromatography (HPLC). The solubility of the precipitate in human plasma was measured by HPLC.

RESULTS

The UV absorption spectrum of the precipitate resembled that of thiopentone. HPLC analysis produced a single peak with the same retention time as thiopentone (4.6 min). In human plasma the solubility of the precipitate was not different from that of thiopentone acid. The solubility of thiopentone was greater than that of the precipitate.

CONCLUSION

The precipitate formed by thiopentone and vecuronium in vitro consisted of thiopentone acid, which was insoluble in human plasma.

摘要

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本文引用的文献

1
The effect of pancuronium on the solubility of aqueous thiopentone.
Can J Anaesth. 1987 Jan;34(1):87-9. doi: 10.1007/BF03007694.
2
Analysis of thiopentone in human plasma by high-performance liquid chromatography.采用高效液相色谱法分析人血浆中的硫喷妥钠。
J Chromatogr. 1978 May 1;145(3):492-5. doi: 10.1016/s0378-4347(00)81383-3.