Kulikov V I, Muzia G I
Biokhimiia. 1996 Mar;61(3):387-403.
The review is concerned with cell metabolites - the platelet activating factor (PAF) and its choline-containing structural analogs. The biological activity of PAF and its analogs are considered. The influence of PAF and its analogs of membrane properties, cell receptors, transmembrane signalling (protein kinase C activation, Ca2+ release) as well as its participation in cell phospholipases A2, C and D activation are considered. The intracellular function of PAF and its analogs is discussed in terms of their influence on prostaglandin and leukotriene biosynthesis as well as with reference to the biological activity of 1-acyl-2-acetyl-sn-glycerols and lysophosphatidylcholine. The function of cell-released PAF and its analogs is considered in connection with their influence on plasma lipoproteins, inter-cell PAF synthesis and different mechanisms of PAF and PAF analog-induced cell activation including cell priming, cell desensitization and receptor-dependent effects. It is concluded that PAF is an intracellular and intercellular mediator, whereas 1-acyl-PAF is an intracellular lipid bioregulator.
该综述关注细胞代谢物——血小板活化因子（PAF）及其含胆碱的结构类似物。文中探讨了PAF及其类似物的生物活性，以及PAF及其类似物对膜特性、细胞受体、跨膜信号传导（蛋白激酶C激活、Ca2+释放）的影响，还讨论了其在细胞磷脂酶A2、C和D激活中的作用。从PAF及其类似物对前列腺素和白三烯生物合成的影响以及1-酰基-2-乙酰基-sn-甘油和溶血磷脂酰胆碱的生物活性方面，讨论了PAF及其类似物的细胞内功能。结合PAF及其类似物对血浆脂蛋白的影响、细胞间PAF合成以及PAF和PAF类似物诱导细胞激活的不同机制（包括细胞致敏、细胞脱敏和受体依赖性效应），探讨了细胞释放的PAF及其类似物的功能。得出的结论是，PAF是一种细胞内和细胞间介质，而1-酰基-PAF是一种细胞内脂质生物调节剂。
