Jazayeri A, Tsibris J C, Hunt L T, Spellacy W N
Department of Obstetrics and Gynecology, University of South Florida Colege of Medicine, Tampa 33606, USA.
Am J Perinatol. 1996 May;13(4):227-30. doi: 10.1055/s-2007-994369.
Erythropoietin (EPO) levels were measured using an ELISA method in umbilical cord plasma from 68 appropriately grown neonates at 27 to 43 weeks of gestation (EGA). A consistent but small (5%) difference was found between the EPO levels in the umbilical artery (Ua), 21.0 +/- 2.5 mlU/mL (mean +/- SEM), and umbilical vein (Uv), 22.0 +/- 2.7 mlU/mL (p < 0.02, n = 30). Significant inverse correlations were found between Ua EPO levels and pO2 (r = -0.44, p < 0.002), pH (r = -0.68, p < 0.0001), as well as base deficit (r = -0.56, p < 0.0001). A significant correlation was found between EGA and Ua EPO from 27 to 43 weeks of gestation (r = 0.45, p < 0.001, n = 68). One and 5 minute Apgar scores did not correlate with EPO. These findings indicate that EPO correlates strongly with cord gas parameters and thus may serve as a clinically useful marker for both subacute fetal distress and chronic uteroplacental insufficiency.
采用酶联免疫吸附测定法（ELISA）检测了68例孕27至43周（根据估计孕龄，EGA）生长正常的新生儿脐带血血浆中的促红细胞生成素（EPO）水平。结果发现，脐动脉（Ua）的EPO水平为21.0±2.5 mIU/mL（均值±标准误），脐静脉（Uv）的EPO水平为22.0±2.7 mIU/mL，两者之间存在持续但较小（5%）的差异（p<0.02，n = 30）。脐动脉EPO水平与血氧分压（pO2）（r = -0.44，p<0.002）、pH值（r = -0.68，p<0.0001）以及碱缺失（r = -0.56，p<0.0001）之间存在显著的负相关。在孕27至43周期间，估计孕龄（EGA）与脐动脉EPO之间存在显著相关性（r = 0.45，p<0.001，n = 68）。1分钟和5分钟Apgar评分与EPO无相关性。这些发现表明，EPO与脐血气参数密切相关，因此可能是亚急性胎儿窘迫和慢性子宫胎盘功能不全的一种临床上有用的标志物。
